Krebs Cycle

Pre-Krebs Cycle-
2 oxygens and a carbon go off from pyruvate to become acedaltihide which bonds to coenzyme a to produce acetal CoA, and goes into Krebs Cycle (2 NADH made in Pre-Krebs cycle).
Predisposition- "genetically predisposed" set up for it to happen.
Acetal CoA comes in and bonds with oxaloacetate. The CoA goes away, and you are left with citrate. Citrate becomes isocitrate by rearranging molecule. In isocitrate, we lose a carbon dioxide and isocitiate (6-carbon) becomes alpha-Ketogluterate (5-carbon molecule) alpha-Ketogluterate gives up another carbon (4-carbon), a coenzyme A will grab it succinyl CoA. CoA breaks away to cause generation of ATP from ADP and P (energy makes this happen). Your new molecule is succinate. Succinate will rearrange to Fumerate, which will release 2 H⁺ and the electrons it takes to bond them producing FADH₂. Fumerate rearranges to malate, malate rearranges to oxaloasetate (loose hydrogen and some electrons), and in doing that, you produce another NADH. Cycle repeats twice.

You will produce: 4 CO₂ - 6 CO₂
6 NADH - 10 NADH
2 FADH₂- 2 FADH₂
2 ATP - 4 ATP

Electrons from all NADH and FADH₂ enter ETS. Molecules then lose H⁺ ions. Then the movement of electrons in the ETS causes the active transport of the hydrogen into one side of the membrane. The hydrogens then use phasilitated diffusion through an ion channel and then produces ATP through the movement. Hydrogens then bone with oxygen taken in and create H₂O.